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Combination Micelles with Improved Drug Encapsulation and Therapeutic Synergy as Novel Nanotherapeutics for NQO1-Targeted Cancer Therapy Ling Zhang,† Zhen Chen,† Kuan Yang,† Chun Liu,† Jinming Gao,‡ and Feng Qian*,† †Department of Pharmacology and Pharmaceutical Sciences and Collaborative Innovation Center

Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 Abstract One of the major challenges in nanomedicine is to improve nanoparticle cell selectivity and adhesion efficiency through designing functionalized nanoparticles of controlled sizes, shapes,

Gao3 1Erik Johnsson School of Engineering & Computer Science, University of Texas at Dallas, Richardson, TX 75080; 2Department of Mechanical Engineering and Mechanics, Lehigh University, 19 Memorial Drive West, Bethlehem, PA 18015; 3Department of Pharmacology, Harold C Simmons Comprehensive Cancer Center

Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States b The Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States a r t

DORMIDONTOVA�,2 *Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390; and �Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, Ohio 44106 Polymer micelles with two different core-forming blocks, poly

The University of Texas Southwestern Medical Center

The University of Texas Southwestern Medical Center

The University of Texas Southwestern Medical Center

The University of Texas Southwestern Medical Center

Saidel a,⁎, Jinming Gao b a Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106–7207, United States b Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390–8590, United States Received 14 November 2006